Post-traumatic stress disorder and its risk factors in bereaved Tibetan adolescents 3 years after the 2010 Yushu earthquake,a cross-sectional study in China

Objectives

This study examined the incidence of symptomatological post-traumatic stress disorder (PTSD) in bereaved Tibetan adolescents 3?years after the 2010 Yushu earthquake, then to identify possible and relational risk factors of PTSD by a cross-sectional study.

Safety of a quadrivalent human papillomavirus vaccine in a Phase 3, randomized,double-blind,placebo-controlled clinical trial among Chinese women during 90 months of follow-up

Background

A quadrivalent human papillomavirus (qHPV) vaccine (HPV6/11/16/18) has demonstrated efficacy and acceptable safety in international studies. However, these studies did not include participants from mainland China, which has a substantial burden of HPV-related disease. This is the first safety report with a follow-up period of up to 90?months from a randomized, double-blind, placebo-controlled trial of qHPV vaccine in Chinese women 20–45?years of age.

食管癌术后康复期患者营养状况及生命质量的纵向研究

目的 了解食管癌术后康复期患者营养状况及生命质量的变化趋势及相关关系。方法 以四川省肿瘤专科医院行食管癌手术治疗的75例患者为研究对象，在患者术后1个月、3个月和6个月时运用患者主观整体营养评估量表进行营养评估，采用肿瘤生命质量测评量表和食管癌患者补充量表进行生命质量评定。结果 食管癌患者术后随时间的延长营养不良发生率由73.4%下降至33.5%。生活质量各维度评分在各评估时间点差异均有统计学意义（P<0.05），功能领域和症状领域在术后1个月与术后3个月、术后6个月比较有统计学意义（P<0.05），术后3个月与术后6个月比较差异无统计学意义（P>0.05）。患者营养状态与躯体、角色、情绪及社会功能呈负相关（P<0.05），与吞咽困难、进食、反流、梗阻、食欲减退、咳嗽症状呈正相关（P<0.05）。结论 食管癌术后1个月患者营养状况及生命质量较差，随时间推移逐渐好转。医护人员应根据患者在不同时间点营养状况及生命质量的变化特点，制定规范化和个体化的延续护理方案，以促进患者术后康复、提高生命质量。     

医院临床技能培训中心在应对疫情专项技能培训中的作用——以南通大学第五附属医院临床技能培训中心为例

2019 年底新型冠状病毒肺炎（以下简称新冠肺炎）疫情发生后，为抗击疫情和保障医护人员自身安全，开展了传染病防护技能专项培训。在本医院的临床技能培训中心，按“三区两通道”设置模拟隔离病区、开发传染病防控专项培训课程，对全体医护人员（特别是一线医护人员）进行传染病防护技能、进出隔离病区等项目实景培训及实战练习。以期迅速有效地提升医护人员传染病防护技能和防护下临床操作的熟练度、精准度，在更好地治疗患者的同时，实现了医护人员“零感染”的目标。同时也说明在医院临床技能培训中心设置模拟隔离病区、开设传染病防护技能课程，并纳入常态化培训考核的必要性和重要性。     

SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/β-catenin signaling

Sex-determining region Y box (SOXs) are expressed in various cells and control cell fate and differentiation in a multitude of physiologic processes. SOX6, a main representative of SOXs, is involved in the regulation of carcinogenesis in various human malignancies. However, the role of SOX6 in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, SOX6 expression in ccRCC and its clinical significance were investigated. In vitro and in vivo assays were used to explore the tumor-related function and the underlying molecular mechanism of SOX6 in ccRCC. We confirmed that SOX6 was frequently downregulated in ccRCC tissues and cell lines. Besides, downregulation of SOX6 was significantly associated with larger tumor sizes, advanced tumor stage, higher Fuhrman grades, and its expression could act as an independent prognostic factor for ccRCC (hazards ratio = 0.590, P = .026). Gain/loss-of-function experiments demonstrated that SOX6 could remarkably inhibit tumor cell growth and foci formation in vitro and xenograft tumorigenesis in vivo, respectively. Mechanistically, SOX6 could influence cell cycle by regulating the G1/the S phase transition and had an inhibitory effect on Wnt/β-catenin signaling as well as its target genes, c-Myc and cyclin D1. Interesting, the tumor-suppressive function of SOX6 was proved to be dependent on its specific high-mobility-group (HMG) domain. In general, our findings indicated that SOX6 was a novel tumor suppressor and prognostic biomarker in ccRCC. SOX6 could inhibit tumor growth by negatively regulating the Wnt/β-catenin signaling pathway in an HMG domain-dependent manner in ccRCC, which might provide a novel therapeutic approach for ccRCC.     

An Integrated Method with PROMETHEE and Conflict Analysis for Qualitative and Quantitative Decision-Making: Case Study of Site Selection for Wind Power Plants

Cognitive Computation - Multiple-criteria decision-making is common in our daily life. The probabilistic linguistic term set is an effective tool to represent both simple and cognitive complex...     

高血压与肠道菌群及其代谢物的相关性研究

肠道菌群在人体形成一个庞大而复杂的微生态系统，有重要的生理意义，参与人体的能量代谢、免疫调节等，肠道菌群及其代谢物在多种疾病的发生、发展中起着重要的作用。我国人群50年来高血压患病率呈明显上升趋势，目前我国约有2亿高血压患者，每10个成年人中有2人患高血压[1]。而在高血压的发生、发展过程中，肠道菌群及其代谢物起着重要作用。本文就高血压与肠道菌群及其代谢物的相关性研究做一综述。     

中医药院校药事管理专业人才素质培养的研究

国内药事管理专业起步较晚，对该领域人才需求突出；中医药行业药事管理专业人才培养及储备尤为重要。从药事管理学科背景出发，结合中医药行业特点，以北京中医药大学为例；提出中医药院校在药事管理专业教育中，应让学生传承中国传统文化，重视以哲学思维为引领，培养以人为本及融合中庸之道的管理能力，掌握中医药理论+通识管理的特色专业课程知识，具备继承不泥古、创新不离宗等综合素质。